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The evolution of our understanding of the formation of thrombin from the postulated thrombokinase of Morawitz to activated Factor X and prothrombinase occurred during a period of nearly 100 years.… Click to show full abstract
The evolution of our understanding of the formation of thrombin from the postulated thrombokinase of Morawitz to activated Factor X and prothrombinase occurred during a period of nearly 100 years. During this time structure–function relationships have emerged and the roles of phospholipid surfaces, the accessory factor, Factor V and its activated form have been clarified. This paper summarizes this story with particular acknowledgement of the seminal contributions of Haskell Milstone.
Keywords:
factor;
prothrombinase;
structure function;
function factor
Journal Title: Journal of Thrombosis and Thrombolysis
Year Published: 2021
Link to full text (if available)
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Journal Title: Journal of Thrombosis and Thrombolysis
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!