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Agelamasines A and B, diterpene alkaloids from an Okinawan marine sponge Agelas sp.

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Two new diterpene alkaloids having an N-methyladenine moiety, agelamasines A (1) and B (2), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1 and 2 were… Click to show full abstract

Two new diterpene alkaloids having an N-methyladenine moiety, agelamasines A (1) and B (2), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses. Agelamasine A (1) is the first diterpene alkaloid with a rearranged (4 → 2)-abeo-clerodane skeleton from a marine source, while agelamasine B (2) is a clerodane diterpene alkaloid.

Keywords: okinawan marine; diterpene alkaloids; sponge agelas; agelamasines diterpene; marine sponge

Journal Title: Journal of Natural Medicines
Year Published: 2017

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