Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A–I (1–9), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were… Click to show full abstract
Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A–I (1–9), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds 4, 5, 6, and 8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20 μM, reducing their viability by 7.5, 18.0, 9.0, and 18.2 %, respectively.
               
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