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Two new ɑ-pyrone derivatives from the endophytic Diaporthe sp. ECN371

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Diaportholides A ( 1 ) and B ( 2 ), two polyketides with ɑ-pyrone moieties, were isolated from the cultures of an endophytic Diaporthe sp. ECN371 isolated from Orixa japonica… Click to show full abstract

Diaportholides A ( 1 ) and B ( 2 ), two polyketides with ɑ-pyrone moieties, were isolated from the cultures of an endophytic Diaporthe sp. ECN371 isolated from Orixa japonica , together with four known polyketides, phomopsolide B ( 3 ), phomopsolidones A ( 4 ) and B ( 5 ), and 5-[(1 R )-1-hydroxyethyl]-γ-oxo-2-furanbutanoic acid ( 6 ). The structures of 1 and 2 were determined by extensive analysis of NMR and MS spectroscopic data. Furthermore, the structure of 2 was confirmed by analyzing the single-crystal X-ray diffraction data. The luciferase reporter gene assay revealed that among all isolated compounds ( 1–6 ), 3 , a known ɑ-pyrone derivative, exhibited agonistic activity against the peroxisome proliferator-activated receptor ɑ, which is an important regulator of lipid metabolism in humans. Graphical abstract

Keywords: derivatives endophytic; two new; endophytic diaporthe; pyrone derivatives; new pyrone; diaporthe ecn371

Journal Title: Journal of Natural Medicines
Year Published: 2022

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