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A highly regio- and enantioselective allylic C-H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate… Click to show full abstract
A highly regio- and enantioselective allylic C-H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes, delivering structurally diverse chiral β-branched a-amino acid surrogates in moderate to high yields and with high levels of regio-, Z / E -, diastereo- and enantioselectivities.
Keywords:
schiff bases;
alkylation dienes;
allylic alkylation;
dienes glycine;
glycine schiff
Journal Title: Science China Chemistry
Year Published: 2020
Link to full text (if available)
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Journal Title: Science China Chemistry
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!