LAUSR

We study the dynamics of a model of membrane vesicle transport into dendritic spines, which are bulbous intracellular compartments in neurons driven by molecular motors. We reduce the lubrication model proposed in Fai et al. (Phys Rev Fluids 2:113601, 2017) to a fast-slow system, yielding an analytically and numerically tractable equation equivalent to the original model in the overdamped limit. The model's key parameters include: (1) the ratio of motors that prefer to push toward the head of the dendritic spine to the motors that prefer to push in the opposite direction, and (2) the viscous drag exerted on the vesicle by the spine constriction. We perform a numerical bifurcation analysis in these parameters and find that steady-state vesicle velocities appear and disappear through several saddle-node bifurcations. This process allows us to identify the region of parameter space in which multiple stable velocities exist. We show by direct calculations that there can only be unidirectional motion for sufficiently close vesicle-to-spine diameter ratios. Our analysis predicts the critical vesicle-to-spine diameter ratio, at which there is a transition from unidirectional to bidirectional motion, consistent with experimental observations of vesicle trajectories in the literature.