LAUSR

Stiff person syndrome (SPS) is a rare neurological disorder, characterised by progressive fluctuating muscular rigidity and spasms. Although the exact pathogenesis is unclear, glutamic acid decarboxylase (GAD) antibody, the enzyme responsible for the synthesis of γ-aminobutyric acid (GABA), is found in approximately 60 to 80% of SPS patients. Up to 5% of all SPS patients are associated with malignancies; however, paraneoplastic SPS is usually not associated with anti-GAD antibodies but with anti-amphiphysin or anti-gephyrin antibodies. We report the case of a patient who presented with paraneoplastic SPS secondary to pancreatic adenocarcinoma that resolved following a Whipple procedure. Subsequently, she had a recurrence of her SPS symptoms 15months after the Whipple procedure, which preceded clinically detected recurrence of pancreatic cancer by 3 months. Case Report