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Plum cultivars grown in Himalayan temperate conditions: physicochemical, antioxidant and antiproliferative activity against three cancer cell lines

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Six plum cultivars were evaluated in terms of physicochemical attributes (fruit and stone length, breadth, thickness, weight, fruit moisture content, ash, pH, fruit color, firmness, total soluble solids, total sugars,… Click to show full abstract

Six plum cultivars were evaluated in terms of physicochemical attributes (fruit and stone length, breadth, thickness, weight, fruit moisture content, ash, pH, fruit color, firmness, total soluble solids, total sugars, reducing sugars and titrable acidity), nutraceutical potential i.e., ascorbic acid, β carotene, anthocyanin, total phenol content, total antioxidant activity (DPPH, FRAP) and antiproliferative potential against human breast cancer cell line (MCF7), neuroblastoma (IMR32) and colon cancer cell line (HCT116). The hydroxycinnamates and flavon-3-ols dominated the phenolic profile. Red fleshed plum cultivar Krassivica showed significantly greater antioxidant activity as shown by lowest IC50 value (1.04 mg/mL) for DPPH assay and FRAP value (13.63 µMFe2+/g). Significant inhibition of all the three cancer cells was observed in a dose dependent manner after exposure to plum extracts. For IMR32, MCF7 and HCT116 lowest IC50 value of 67.90, 51.48 and 71.10 µg/mL was observed in Krassivica. Thus, Krassivica can be introduced as a cultivar with good physicochemical characteristics and high neutraceutical potential, making it a preferable choice for fresh use and processing.

Keywords: plum cultivars; three cancer; cancer cell; cancer; activity

Journal Title: Journal of Food Measurement and Characterization
Year Published: 2018

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