LAUSR

Purpose Cardiovascular diseases (CVD) are one of the leading causes of mortality in obese patients. In this study, we investigated the effects of laparoscopic sleeve gastrectomy (LSG) operation on carotid intima-media thickness (CIMT), epicardial fat thickness (EFT), and serum endocan levels, which are independent predictors of subclinical atherosclerosis. Materials and Methods A total of 47 patients (35 females and 12 males) with a mean age of 38 ± 10.48 with standard indications for LSG were prospectively included in the study. Mean CIMT values with B-mode duplex ultrasound, EFT measurements with standard transthoracic 2D echocardiography, and serum endocan levels were measured before the operation and 6 months after the operation. Delta (Δ) values were obtained by subtracting sixth month values from baseline values. Results Body mass index (BMI) decreased significantly from an average of 47.31 ± 6.10 to 37.25 ± 5.61 kg/m 2 in the sixth month after LSG ( p  < 0.001). EFT, CIMT, and serum endocan values decreased significantly in the sixth month after surgery (0.67 ± 0.15 vs. 0.60 ± 0.14 mm, p  < 0.001; 1.07 ± 0.05 vs. 1.00 ± 0.14 mm, p  < 0.001; and 89.18 ± 66.22 vs. 37.74 ± 15.37, p  < 0.001, respectively). There were mild-moderate positive relationships between Δ-BMI and the values of EFT and CIMT ( r  = 0.386, p  = 0.007 and r  = 0.314, p  = 0.024, respectively). We also found weak linear relationships between Δ-BMI and Δ-endocan ( r  = 0.267, p  = 0.036), and between Δ-EFT and Δ-CIMT ( r : 0.221; p : 0.046). Conclusion LSG can lead to reduction in the risk of cardiovascular disease by providing improvements in CIMT, EFT, and serum endocan values, which reflect early structural atherosclerotic changes in patients with severe obesity.