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Design and synthesis of an AIE-active fluorogen with red emission and its biological application

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A novel triphenylamine-base derivative L containing pyridine and terpyridine was designed and synthesized. Compound L exhibited distinct aggregation-induced emission (AIE) behavior in water–ethanol and also displayed a threefold increase in… Click to show full abstract

A novel triphenylamine-base derivative L containing pyridine and terpyridine was designed and synthesized. Compound L exhibited distinct aggregation-induced emission (AIE) behavior in water–ethanol and also displayed a threefold increase in the intensity of luminescence at 608 nm. Furthermore, confocal microscopy imaging demonstrated that compound L displays low toxicity and brights red fluorescence in mitochondria in living HepG2 cells. Inherent from the mitochondrial-targeting ability of pyridine moiety and the AIE characteristic of triphenylamine group, compound L could be employed as a fluorescent probe in the near-infrared region for living cell imaging.

Keywords: design synthesis; aie active; fluorogen red; synthesis aie; active fluorogen; emission

Journal Title: Chemical Papers
Year Published: 2018

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