LAUSR

ObjectiveTo compare and analyze functional brain response characteristics by applying acupuncture or moxibustion to Zusanli (ST 36) in patients with functional dyspepsia (FD) and investigate the differences of central action mechanism resulting from acupuncture or moxibustion.MethodsA total of eligible 24 FD cases were divided into two blood-oxygen-level dependent (BOLD) sequences for functional magnetic resonance imaging (fMRI) scan. The amplitude of low frequency fluctuation (ALFF) analyses were conducted on the data of location phase, structure phase, resting state before acupuncture/moxibustion, working state during acupuncture/moxibustion and resting state after acupuncture/moxibustion using Data Processing Assistant for Resting-State fMRI (DPARSF) software.ResultsAcupuncture and moxibustion produced significant differences in functional brain response. The working state during acupuncture/moxibustion mainly decreased ALFF values in the right supramarginal gyrus, right superior parietal lobule, right frontal gyrus, upper right occipital lobe, right precuneus and right cingulate gyrus. At the same time, it increased ALFF values in the left cerebellum, right caudate nucleus, right cerebellum and left inferior gyrus. The differences during the resting state after acupuncture/moxibustion were significantly smaller than the working state in intensity and size. It mainly resulted in decrease in ALFF values in the right postcentral gyrus and right supramarginal gyrus and increase in ALFF values in the left precuneus, orbital part of inferior frontal gyrus and right cerebellar peduncles.ConclusionNeedling and moxibustion at Zusanli (ST 36) can produce significant differences in immediate functional brain response.摘要目的比较分析针刺与艾灸足三里穴治疗功能性消化不良(FD)的脑功能响应特征, 探索针刺与艾灸中枢作 用机制的差异。方法选取符合条件的FD 患者24 例, 分针刺、艾灸两个BOLD 序列进行功能磁共振成像(fMRI) 扫描, 每个序列分为定位相、结构相、针刺/艾灸前静息态、针刺时/艾灸时任务态、针刺/艾灸后静息态, 采集数 据运用DPARSF 软件进行低频振幅(ALFF)分析。结果针刺与艾灸时的脑功能响应具有明显差异, 针刺时/艾灸时 任务态比较主要引起了右缘上回、右顶上小叶、右额中回、右枕叶上部、右楔前叶、右扣带回中部等脑区ALFF 值降低, 以及左小脑、右尾状回、右小脑、左小脑脚、左颞下回等脑区ALFF 值的升高; 针刺/艾灸后静息态的比 较差异在强度和区域大小上均明显小于任务态, 主要引起了右中央后回、右缘上回脑区ALFF 值的降低,以及左楔 前叶、左额下回眶部、右小脑脚脑区ALFF 值的升高。结论针刺与艾灸FD 患者足三穴的即时脑功能响应区域 有明显差异。