LAUSR

ObjectiveTo observe the effects of acupuncture at the follicular phase on ovarian blood supply and pregnancy outcomes in patients who received in vitro fertilization/intracytoplasmic sperm injection-embry transfer (IVF/ICSI-ET) of assisted reproductive technology (ART).MethodsA total of 169 IVF/ICSI-ET female recipients from the Reproductive Center of Xiehe Hospital, Tongji Medical College, Huazhong University of Science & Technology were randomized into an observation group (57 cases), a placebo group (54 cases) and a control group (58 cases). The observation group received acupuncture during the follicular phase, meanwhile the placebo group received placebo-acupuncture, and the control group did not receive acupuncture. The hemodynamic index, biochemical pregnancy rate and clinical pregnancy rate of each group were observed, respectively.ResultsAs to the ovarian arterial hemodynamic index, the pulsatility index (PI), resistance index (RI), and the systolic-to-diastolic peak velocity ratio (S/D) of the observation group were (0.819±0.131), (0.552±0.055) and (2.306±0.512), respectively, obviously lower than those in the placebo group and the control group, and the differences were statistically significant (all P<0.05), but there were no statistically significant differences between the placebo group and the control group (all P>0.05). As to the biochemical pregnancy rate and clinical pregnancy rate, the biochemical pregnancy rate in the observation group was 64.9% and the clinical pregnancy rate was 52.6%, which were significantly higher than those in the placebo group and the control group, and the differences were statistically significant (all P<0.05), while there were no significant differences between the placebo group and the control group (both P>0.05).ConclusionAcupuncture treatment during the follicular phase can improve ovarian blood supply and pregnancy rate in those receiving IVF/ICSI-ET.摘要目的观察在卵泡期针刺对接受辅助生育技术(ART)中体外受精/单精子卵细胞质内注射-胚胎移植(IVF/ICSI-ET)者的卵巢血供及妊娠结局的影响。方法共纳入169例在华中科技大学同济医学院附属协和医院生殖中心接受IVF/ICSI-ET的女性, 随机分为观察组(57例)、安慰组(54例)和对照组(58例)。观察组在卵泡期接受针刺疗法, 安慰组在同一时段接受安慰针刺, 对照组不接受任何针刺。分别观察每组卵巢血流动力学指数、生化妊娠率和临床妊娠率。结果在卵巢动脉血流动力学指数方面, 观察组搏动指数(PI)、血流阻力指数(RI)、收缩期与舒张末期血流速比(S/D)分别为(0.819±0.131)、(0.552±0.055)和(2.306±0.512), 均明显低于安慰组和对照组, 组间差异均有统计学意义(均P<0.05); 而安慰组和对照组之间差异无统计学意义(均P>0.05)。在生化妊娠率及临床妊娠率方面, 观察组生化妊娠率为64.9%, 临床妊娠率为52.6%, 均明显高于安慰组和对照组, 差异均有统计学意义(均P<0.05), 但安慰组和对照组之间差异无统计学意义(均P>0.05)。结论在卵泡期予以针刺治疗能够改善接受IVF/ICSI-ET者的卵巢血供及提高妊娠率。