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MicroRNA-8 and its target gene, u-shaped (ush), regulate body size in Drosophila. As the mouse homolog of the Drosophila miR-8, whether the miR-200 family has similar functions and how they… Click to show full abstract
MicroRNA-8 and its target gene, u-shaped (ush), regulate body size in Drosophila. As the mouse homolog of the Drosophila miR-8, whether the miR-200 family has similar functions and how they perform their regulatory roles in body size control is unknown. In order to discover the biological function of the miR-200s in vivo, we generated mice lacking the miR-200b/200a/429 gene cluster using the Cre/loxp system. miR-200b/200a/429 null mutant mice were viable, fertile, and showed normal development.
Keywords:
floxed allele;
microrna 200;
generation floxed;
mouse microrna;
allele mouse;
mouse
Journal Title: Applied Biochemistry and Biotechnology
Year Published: 2017
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Journal Title: Applied Biochemistry and Biotechnology
Year Published: 2017
Link to full text (if available)
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recommendations!