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Mediastinal lymph node metastases 6 years after latero-cervical lymph node dissection for metastases from undiagnosed occult papillary thyroid carcinoma

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The incidence of papillary thyroid cancer has progressively and dramatically increased in the last 3 decades, mostly due to increased detection of papillary thyroid microcarcinoma (mPTC) and the introduction of… Click to show full abstract

The incidence of papillary thyroid cancer has progressively and dramatically increased in the last 3 decades, mostly due to increased detection of papillary thyroid microcarcinoma (mPTC) and the introduction of cancer screening programs [1, 2]. According to World Health Organization Classification of Thyroid Tumors, mPTC refers to small thyroid carcinomas ≤ 10 mm in maximum diameter. They could be distinguished in presurgical and postsurgical detection [3, 4]. mPTCs are found approximately in 6–36% of the population at autopsy. Most of them remain clinically silent and only a small number (2%) progresses [5]. Despite the very low mortality rates, loco regional recurrence is a common clinical problem. Some mPTC have lymph node metastases (16–64%) and multiple tumor localizations (23–33%) at presentation, which are both associated with distant metastases and a less favorable outcome, including increased mortality [5]. For this heterogeneous behavior the follow-up and the management of mPTC patients is different, depending on the risk stratification [6]. Here, we report the case of a mediastinal lymph node metastases 6 years after latero-cervical lymph node dissection for metastases from undiagnosed occult PTC [7].

Keywords: papillary thyroid; lymph node; lymph; node metastases

Journal Title: Endocrine
Year Published: 2020

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