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A catalyst-free multicomponent reaction capable of affording a wide range of eighteen novel chromeno[4,3-b]quinolone derivatives (6a–6r) via one-pot two-step domino protocol, in ethylene glycol is reported. Catalyst-free conditions along with… Click to show full abstract
A catalyst-free multicomponent reaction capable of affording a wide range of eighteen novel chromeno[4,3-b]quinolone derivatives (6a–6r) via one-pot two-step domino protocol, in ethylene glycol is reported. Catalyst-free conditions along with green solvent system make the process eco-friendly as well as economical. High yields of the products were obtained in short reaction times by forming three new bonds and one stereocenter in a single operation. The salient features of the present protocol are short reaction times, eco-friendly solvents, high yields and easy work-up procedure.Graphical Abstract:SYNOPSIS A catalyst-free multicomponent reaction capable of affording a wide range of novel chromeno[4,3-b]quinolone derivatives via one-pot two-step domino protocol, in ethylene glycol is reported. Catalyst-free conditions along with green solvent system make the process eco-friendly and economical.
Journal Title: Journal of Chemical Sciences
Year Published: 2017
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