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Drawing on event system theory, this study explored the mechanism by which COVID-19 pandemic strength (including criticality, disruption, and novelty) influences work fatigue through the mediating role of occupational calling. A two-wave field study was conducted with 857 Chinese police officers using COVID-19 pandemic strength, occupational calling, and work fatigue questionnaires. The results showed that COVID-19 pandemic criticality had a positive effect on work fatigue and occupational calling, and that occupational calling mediated the direct link between COVID-19 pandemic criticality and work fatigue. Additionally, the first and second stages of the mediating effect were jointly moderated by COVID-19 pandemic disruption and novelty. When COVID-19 pandemic disruption and novelty were high, the positive relationship between COVID-19 pandemic criticality and occupational calling, and the mediating role of occupational calling, were stronger. The negative relationship between occupational calling and work fatigue was strengthened when COVID-19 pandemic disruption was high and novelty was low. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.