LAUSR

In this study, we characterized a QD-labeled nonenveloped aquareovirus. Our results showed that QDGCRVs maintained their native particle properties and showed excellent infectivity in host cells. To the best of our knowledge, this is the first study reporting the realization of in situ real-time tracking with fluorophores in live cells by utilizing a QD-labeled non-enveloped aquareovirus. Although the QD-GCRV can’t track the whole process of viral infection, this approach will provide a promising prospect for further studies of the molecular mechanisms of viral entry into host cells during aquareovirus infection.