Oxidative stress is significantly associated with chronic arsenic exposure in persons exposed to moderate-to-high level of environmental arsenic. However, the response varies widely among persons within similar exposure level. To… Click to show full abstract
Oxidative stress is significantly associated with chronic arsenic exposure in persons exposed to moderate-to-high level of environmental arsenic. However, the response varies widely among persons within similar exposure level. To study whether Glutathione-S-Transferase (GST) gene polymorphism plays any pivotal role in this variation, total number of 115 chronic arsenic-exposed study subjects without arsenic-induced cancer from School of Tropical Medicine, Kolkata and from arsenic-exposed districts of West Bengal were recruited for this study. Concentration of arsenic in their urine and water, extent of clinical manifestation, GST status and protein carbonylation, and 8-oxo-2′-deoxyguanosine status were determined. Genetic polymorphism of GSTM1 and T1 were significantly associated (p < 0.05) with degree of protein carbonylation and 8-oxo-2′-deoxyguanosine in moderate-to-high degree of arsenic exposure groups. Persons having null genotype have significantly increased level of protein carbonylation and 8-oxo-2′-deoxyguanosine in comparison to persons with GSTM1 or GSTT1 non-null genotype of the same arsenic exposure group. Degree of protein carbonylation and urinary 8-oxo-2-deoxyguanosine is positively correlated with GST null genotype.
               
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