LAUSR

Hashimoto’s thyroiditis is an autoimmune disorder of the thyroid gland. In Hashimoto disease, the immune system damages the follicular cells of the thyroid gland through humoral and cellular-mediated responses which result in diminishing production of thyroid hormones in the blood over time. Using a patient-specific model of Hashimoto’s thyroiditis, we describe the natural history of Hashitoxicosis in genetically susceptible individuals. Hashitoxicosis means a sudden leakage of thyroid hormones from the gland. The main result of this present work is to show the existence of a homoclinic orbit which forms the boundary for the asymptotically stable interior diseased steady state. This homoclinic orbit corresponds to the clinical condition of Hashitoxicosis.