LAUSR

A simple, rapid and effective protocol for the synthesis pyrido[2,3-d:6,5-d′]dipyrimidines has been developed via the one-pot multi-component reaction of arylaldehydes, 2-thiobarbituric acid and NH4OAc using nano-[SiO2-R-NMe2SO3H][Cl] as a mesoporous nanaocatalyst in solvent-free conditions. The remarkable features of this protocol include superiority relative to the reported methods in terms of two or more of these items: the reaction times, yields, the reaction temperature and conditions. Graphical Abstract Effective and rapid synthesis of pyrido[2,3-d:6,5-d′]dipyrimidines catalyzed by a mesoporous recoverable silica-based nanomaterial. Effective and rapid synthesis of pyrido[2,3-d:6,5-d′]dipyrimidines catalyzed by a mesoporous recoverable silica-based nanomaterial.