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Monte Carlo Simulations of the photo-thermal cancer therapy of melanin

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In this study, we performed Monte Carlo calculations to investigate photo-thermal effects on melanoma therapy. For this purpose, we simulated the light propagation in biological tissue. The propagation of laser… Click to show full abstract

In this study, we performed Monte Carlo calculations to investigate photo-thermal effects on melanoma therapy. For this purpose, we simulated the light propagation in biological tissue. The propagation of laser light originates from a source point inside a single layer of light skin with a concentration of melanosomes $$(f_{\text{mel}} = 3\% )$$ . This single layer includes the epidermal with a thickness of 60 $$\upmu{\text{m}}.$$ Various important wavelengths are applied for photo-thermal therapy (PTT), such as Alexandrite laser, Ruby laser, and Nd:YAG, respectively. Accordingly, a single layer of skin is exposed to laser. It is demonstrated that the exposure to laser is a suitable option at a wavelength of $$\lambda =$$ 755 nm, which is useful to improve the therapeutic treatment compared to the lasers of wavelengths of $$\lambda =$$ 694 nm and $$\lambda =$$ 1064 nm, respectively. It is therefore possible to enhance the thermal treatment for light-skinned patients. The evaluation of temporal and spatial distributions is investigated versus the temperature, while the effects of relaxation time and thermal damage on the epidermal are involved.

Keywords: therapy; monte carlo; simulations photo; single layer; photo thermal; carlo simulations

Journal Title: Indian Journal of Physics
Year Published: 2021

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