LAUSR

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy in the world, and it is extremely rare that HNSCC occurs with salivary gland tumor(s). Here, we presented a rare case that squamous cell carcinoma of floor of mouth occurred simultaneously with Warthin’s tumor in the submandibular gland. A 65-year-old Chinese male presented with a 6-month history of an ulcer on the floor of the mouth and preoperative biopsy pathological examination demonstrated it was squamous cell carcinoma. Postoperative microscopic examination unexpectedly found the carcinoma occurred simultaneously with two Warthin’s tumors in the right submandibular gland. This case serves as a reminder to oral surgeons that in head and neck carcinomas, enlarged lump may be caused by inflammation or secondary primary focus rather than lymph node metastasis. Recognition and implication of the unexpected pathologic findings in patients with head and neck cancer are thus worth of studying.