LAUSR

Malignancy-associated cholestasis is generally observed secondary to widespread hepatic metastasis or biliary tract obstruction. However, cholestasis may be a part of paraneoplastic manifestation of some malignancies. Nonmetastatic hepatic dysfunction without jaundice (Stauffer’s like syndrome) can be a part of the neoplastic process that causes liver enzyme elevation and cholestasis without any obstruction of the hepatobiliary tree. Therefore, it is designated as a paraneoplastic syndrome (PNS) of debatable pathophysiology. This phenomenon is seen most commonly with renal cell carcinoma (RCC) and rarely with other malignancies like leiomyosarcoma, prostatic adenocarcinoma, and bronchogenic carcinoma [1]. Here, we report one such rare presentation of paraneoplastic transaminitis in a patient of ovarian malignancy.