LAUSR

BACKGROUND Cardiovascular diseases (CVDs) are major causes of mortality in developing countries. One of the challenges during CVDs studies is the creation of a damaged model of the heart. Many injured models of cardiac diseases are created by using chemical and biological materials. Many approaches were applied to simulate heart injury for investigating CVDs. In previous years, animal models could be used as a useful pattern in many investigations about the pathogenesis of the heart. Nowadays it has been proven that there are many differences between human and animal models in terms of responses or reactions to treatments. For such reasons, researchers prefer to use cellular models alongside the animal models for studying heart diseases. PURPOSE In this review, we collected information about some chemical and biological materials used to create damaged-heart models both in vitro and in vivo. After explaining the materials that induce cardiac damage, we explicate some methods for repairing the damage of heart. Finally, the role of extracellular vesicles as an important biological candidate for repairing heart damage is briefly discussed. CONCLUSION This mini-review tried to explain some methods which can induce cardiac damage and repair of heart cells by use chemical and biological materials. We considered that various molecular pathways play a role in restoration and that most of these pathways are connected in a complex network and, to this end, different chemicals and drugs have been studied to date. Nonetheless, more studies are needed to ensure the performance and safety of the drugs and chemicals produced.