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We read with interest the recently published article by Pramanik, et al. [1]. The study reported inconsistent trends in serum vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP1) in 108… Click to show full abstract
We read with interest the recently published article by Pramanik, et al. [1]. The study reported inconsistent trends in serum vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP1) in 108 patients with progressive pediatric solid tumors who received metronomic chemotherapy or placebo [1]. While higher baseline serum VEGF levels predicted inferior overall survival, authors found that responders with metronomic chemotherapy had significantly lower VEGF levels at baseline compared with non-responders. Further, there was no association of serial VEGF levels with response to metronomic chemotherapy.
Journal Title: Indian Pediatrics
Year Published: 2020
Link to full text (if available)
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