LAUSR

Background Diabetes mellitus is a metabolic disorder caused by impaired glucose metabolism. Coenzyme Q10 is an endogenous vitamin with significant antioxidant properties. Aims and objective The aim of our study is to investigate the protective effect of coenzyme Q10 against streptozotocin-induced diabetic rats. Materials and methods Five groups of rats were used as follows: normal control (given normal saline), diabetic control (STZ 50 mg/kg b.w., i.p.), coenzyme Q10-treated diabetic rats (10 mg/kg b.w.), glibenclamide-treated diabetic rats (0.6 mg/kg b.w.) as standard group, and drug alone-treated group (coenzyme Q10 10 mg/kg b.w.). The rats were sacrificed after the study duration of 30 days. Biochemical and antioxidant parameters and histopathological evaluation were carried out in experimental rats. Results and discussion The diabetic control group showed significant alterations in biochemical and histological parameters. Coenzyme Q10 was able to bring back the altered parameters to normal levels which were similar to that of the glibenclamide-treated group. Conclusion Coenzyme Q10 could, therefore, be used as an adjunct in the management of diabetes. Antidiabetic activity of conenzyme Q10