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Four new alkaloids, ficuhismines A–D (1–4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent… Click to show full abstract
Four new alkaloids, ficuhismines A–D (1–4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1–2) or with a N-oxide motif (2–4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC50 value of 0.52 ± 0.11 μM.
Keywords:
constituents ficus;
ficus hispida;
antiinflammatory activity;
hispida antiinflammatory;
alkaloid constituents
Journal Title: Natural Products and Bioprospecting
Year Published: 2020
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Journal Title: Natural Products and Bioprospecting
Year Published: 2020
Link to full text (if available)
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recommendations!