LAUSR

Air pollution adversely affects skin, leading to skin inflammation and premature skin aging. Plant derived antioxidant compounds have been considered to be promising in discovery of effective agents for the protection of skin from the damage by air pollutants. Our previous studies demonstrated that Averrhoa carambola fruit (known as star fruit) is rich in flavonoid C -glycosides with unique structures and potent antioxidant activity. Thus, the star fruit extract (SFE) and main flavonoid C -glycoside components, carambolasides I, J, and P ( 1 – 3 ), carambolaflavone B ( 4 ), and isovitexin 2″- O -α- l -rhamnoside ( 5 ), were investigated for the activity against air pollutant stress in human epidermis. As a result, SFE and compounds 1 – 5 exhibited significant inhibitory activity against protein carbonylation in oxidative-stressed stratum corneum with the best activity being shown by compound 3 . SFE and compounds 2 – 5 were also active against engine exhaust-induced protein carbonylation in stratum corneum. When further evaluated, SFE and compound 3 significantly inhibited gene expression of the key inflammation mediators IL-1α and COX-2 in PM-stressed keratinocytes. The results indicated that SFE and the flavonoid C -glycosides are potentially effective against air pollutant-induced skin inflammation and premature aging. Graphical Abstract