LAUSR

The aim of this work is to review the role of advanced non-invasive imaging, such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT), in malignant melanomas and non-melanoma skin cancers (NMSCs) using data coming from the most recent literature, with a particular highlight on the results of the European experience. Examination with RCM and OCT increases the accuracy of diagnosis. The most recent diagnostic clues for melanoma and NMSCs are revised. In addition, the application of these techniques in presurgical margin definition and in monitoring the efficacy of topical therapies is discussed. Skin cancer incidence is continuously increasing. While melanoma and squamous cell carcinoma are high-risk skin cancers, basal cell carcinoma can progressively infiltrate and damage the surrounding tissues. Physicians should consider that advanced non-invasive techniques may be employed for an early and accurate diagnosis and an improved management of skin cancers.