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Carbon-based leaving group capability of Meldrum’s acid in substitution reactions: a new strategy toward the synthesis of 4-phenyl-3, 4-dihydro-2H-benzo[g]chromene-2, 5, 10-triones

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An efficient and straightforward method for the synthesis of new 5,5′-(2-benzylidenemalonyl)bis(2,2-dimethyl-1,3-dioxane-4,6-dione) derivatives by the reaction of Meldrum’s acid and aldehydes under mild reaction conditions is reported. Furthermore, the leaving group… Click to show full abstract

An efficient and straightforward method for the synthesis of new 5,5′-(2-benzylidenemalonyl)bis(2,2-dimethyl-1,3-dioxane-4,6-dione) derivatives by the reaction of Meldrum’s acid and aldehydes under mild reaction conditions is reported. Furthermore, the leaving group potency of Meldrum’s acid molecules toward the synthesis of 3,4-dihydro-2H-benzo[g]chromene-2,5,10-triones is investigated.Graphical Abstract

Keywords: leaving group; meldrum acid; toward synthesis; synthesis; dihydro benzo

Journal Title: Journal of the Iranian Chemical Society
Year Published: 2017

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