LAUSR

Pseudotumor cerebri (PTC) is a rare neurological disorder characterized by increased intracranial pressure in the absence of any intracranial space-occupying lesion. PTC may be primary or occur secondary to certain conditions. In secondary cases, some conditions including certain medications, endocrine abnormalities, autoimmune disorders, anemias, infectious or postinfectious processes, and cranial venous outflow abnormalities have been identified as causative agents [1]. Methotrexate (MTX) is one of the most effective and widely used medications for treating juvenile idiopathic arthritis (JIA) and other inflammatory types of arthritis [2]. However, MTX may result in adverse effects including hepatic, pulmonary, and renal toxicity as well as lymphoproliferative disorders and predisposition to infection [2, 3]. There has been only one report of PTC in association with MTX in an adult patient in the literature [4]. We report a case of PTC in a patient with JIA due to MTX therapy. To our knowledge, this is the first case of MTX-induced PTC in children.