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A green and efficient synthesis of 3-pyrazolyl indoles was developed by the cyclocondensation reaction of β-ethylthio-β-indolyl-α, β-unsaturated ketones with semicarbazide hydrochloride as hydrazine equivalent in the presence of 3 equiv.… Click to show full abstract
A green and efficient synthesis of 3-pyrazolyl indoles was developed by the cyclocondensation reaction of β-ethylthio-β-indolyl-α, β-unsaturated ketones with semicarbazide hydrochloride as hydrazine equivalent in the presence of 3 equiv. of PEG-400(1a/PEG mole ratio of 1:3) in reflux water. This procedure did not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.
Keywords:
efficient synthesis;
synthesis pyrazolyl;
green efficient;
pyrazolyl indoles
Journal Title: Chemical Research in Chinese Universities
Year Published: 2019
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Journal Title: Chemical Research in Chinese Universities
Year Published: 2019
Link to full text (if available)
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recommendations!