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A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoacetate and ethyl 3-aminocrotonate was developed. Operational… Click to show full abstract
A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoacetate and ethyl 3-aminocrotonate was developed. Operational simplicity, mild reaction conditions and eco-friendliness are the key features of this protocol.
Keywords:
synthesis dihydropyridine;
synthesis;
calcium channel;
papain catalyzed;
channel antagonists
Journal Title: Chemical Research in Chinese Universities
Year Published: 2019
Link to full text (if available)
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Journal Title: Chemical Research in Chinese Universities
Year Published: 2019
Link to full text (if available)
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recommendations!