LAUSR

In their comments on our recent paper, Standing et al. [1] raise questions about the plausibility of the (de)maturationfunction used to describe differences in the clearance of lamotrigine, where patients younger than 2 years of age show, on average, a higher clearance than adults after correction for body weight. The authors discuss three possible scenarios that could lead to model misspecification. Whilst their arguments highlight important points to consider during model development and evaluation, we contest these points on a case-by-case basis and provide additional evidence for the increase in clearance and proposed (de)maturation function.