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Copper involvement in glutamatergic transmission in physiology and disease as revealed by magnetoencephalography/electroencephalography (MEG/EEG) studies

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Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. The sporadic late onset form of the disease is a multifactorial complex disorder influenced by genetic and… Click to show full abstract

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly. The sporadic late onset form of the disease is a multifactorial complex disorder influenced by genetic and environmental factors. Evidence about the involvement of copper deregulation in AD is overwhelming, encompassing in vitro, experimental models (ref. 1 additional material), clinical, neurophysiological, genetic and meta-analyses studies. An overview of the most relevant findings with a focus on the plasticity phenomena as revealed by magnetoencephalography/electroencephalography (MEG/EEG) studies in living individuals is provided herein. Brain copper homeostasis

Keywords: meg eeg; magnetoencephalography electroencephalography; disease; revealed magnetoencephalography; physiology; electroencephalography meg

Journal Title: Aging Clinical and Experimental Research
Year Published: 2019

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