LAUSR

Nanozyme is a promising field that offers the substitution for natural enzymes using various nanomaterials. Various nanomaterials with peroxidase-like activity were investigated. Among them, transition metal chalcogenides were explored as promising nanozymes due to their excellent enzyme-mimicking activities. However, ruthenium selenide has not been studied as a peroxidase mimic because of the difficulty for synthesis. Herein, we prepared ruthenium selenide nanomaterial with ordered mesoporous structure (P-RuSe2) employing KIT-6 silica as the template. The composition and structure of P-RuSe2 were fully characterized. Further, its peroxidase-like activity was investigated. P-RuSe2 possessed excellent peroxidase-mimicking activity, which catalyzed the oxidation of peroxidase substrates, including 3,3′,5,5′-tetramethylbenzidine, o-phenylenediamine, and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) in the presence of H2O2. Moreover, P-RuSe2 exhibited higher peroxidase-like activity when compared with several representative nanozymes as well as bulk RuSe2. To demonstrate its potential applications, the colorimetric detection systems for H2O2 and glucose were successfully constructed based on P-RuSe2 nanozyme.