LAUSR

Abstract Thrombotic thrombocytopenic purpura, Shiga toxin-associated hemolytic-uremic syndrome and atypical hemolytic-uremic syndrome often present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. These disorders are often classified as thrombotic microangiopathies, which in turn are considered synonymous with the syndrome of MAHA and thrombocytopenia. In this chapter, a mechanistic scheme of classifying disorders that may cause the syndrome of MAHA and thrombocytopenia is delineated and the pertinent features of these three disorders are reviewed.