LAUSR

aposi’s Sarcoma (KS) is a multifocal angioproliferative neolasm associated with infection by Human Herpes Virus type (HHV8).1,2 We retrospectively studied 38 biopsy-proven KS diagosed at our department between 2010 and 2019. The patients’ mean age was 60.5 years (range 35--84). he population was mostly male (n = 33, 86.8%) and Cauasian (n = 31, 81.6%). The epidemic (HIV-associated) subtype predominated (16 ases; 42.1%), followed by the classic (n = 12; 31.6%) and vinorelbine in 1 (4%). Fourteen patients (36.8%) needed second and/or third-line therapies, with local (laser CO2, cryotherapy, radiotherapy, intralesional vinblastine) and/or systemic (doxorubicin, bleomycin, vinorelbine, vinblastine, alfa interferon, paclitaxel) approaches in variable combinations. Partial and/or complete response was achieved in the majority (65.8%) of cases. A third developed -mainly mild (venous stasis and/or lymphedema) -complications. However, transformation to an anaplastic variant arose in one case (Fig. 2) and another patient was subsequently diagnosed with non-Hodgkin lymphoma. Although overall mortality was 36.8%, mortality directly related to KS was only 8% (n = 3). Two patients had classic KS: one died aged 83 following transformation to anaplastic KS despite four cycles of bleomycin; the other died due to visceral p i s T t i b