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RATIONALE AND OBJECTIVES To evaluate the feasibility of simultaneous multislice (SMS)-accelerated, readout-segmented echo-planar imaging (rs-EPI, RESOLVE) with the use of special-purpose coils for head and neck assessment, particularly in patients diagnosed with head and neck malignant tumors, through comparison with the conventional RESOLVE and RESOLVE with readout partial-Fourier technique (RESOLVE-RPF). MATERIALS AND METHODS Twenty-five healthy volunteers and 24 patients with histologically proven malignant head and neck tumors were included in this prospective study. The MR exam included conventional RESOLVE, RESOLVE-RPF, prototypic SMS-RESOLVE, and prototypic SMS-RESOLVE with special-purpose coils (SMS-RESOLVE + Coils), acquired at b-values of both 0 and 800 s/mm2. Image quality was evaluated qualitatively (reader score) and quantitatively (tumor distortion, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), SNR efficiency) and compared. For volunteer imaging, the image quality of target tissues at three different typical levels (oropharyngeal, hypopharyngeal, and thyroid level) were evaluated. For patient imaging, the image quality of primary tumors and metastatic lymph nodes was evaluated. RESULTS The acquisition time was 3:37 minutes for RESOLVE, 2:58 minutes for RESOLVE-RFP, 2:01 minutes for SMS-RESOLVE and 2:01 minutes for SMS-RESOLVE + Coils, with a 44% reduction compared to the conventional RESOLVE. No significant differences in the reader scores, tumor distortion, or ADC values of the lesions were found among the protocols. The SNR and CNR at the oropharyngeal and hypopharyngeal level of SMS-RESOLVE + Coils were markedly improved and significantly higher than those of RESOLVE, as well as the SNR, SNR efficiency of tumors and lymph nodes. No significant differences in quantitative measurements were found at the thyroid level. CONCLUSION SMS-RESOLVE + Coils protocol is an effective and promising approach to optimally reducing the total acquisition time, and could be a good alternative with a superior SNR and SNR efficiency in comparison with conventional RESOLVE. However, the limited application in the lower neck region needs further investigation.