LAUSR

The cardiac atria secrets polypeptide hormones usually called natriuretic peptides (NPs). These substances play a relevant role in the blood pressure regulation. The objective of the study was to estimate the effects of aging on the secretory apparatus of NPs in cardiomyocytes of the right atrium. Twenty male Wistar rats were studied: 10 young animals aged 3 months old (237 ± 27 g; mean ± SD) and 10 old animals aged 20 months old (450 ± 68 g; mean ± SD). The systolic blood pressure was verified instants before the moment of the euthanasia. Electron micrographs were prepared to quantify the area and density of the NP granules and the relative volumes of the endoplasmic reticulum, Golgi complex, and mitochondria. In addition, the number of pores per 10 μm of karyotheca was another variable evaluated. The significance of the results between the two groups evaluated was analyzed by the Student's t test (p < 0.05). The cardiomyocytes obtained from animals of the old group showed decreased in sectional area and density of secretory granules of NP and lower relative volume of endoplasmic reticulum, Golgi complex, and mitochondria compared with the young rats. Moreover, the quantitative density of nuclear pores was significantly lower compared with the youngers. CONCLUSION: Aging causes hypotrophy of the cardiomyocytes of right atrium, similar to what occurs in ventricular cardiomyocytes.