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Prevalence of Control Groups in Cardiovascular Clinical Trials: An Analysis of ClinicalTrials.gov from 2009 through 2019.

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Clinical trials provide the foundational evidence that guide many patient-facing decisions however, the therapeutic effect and safety of an intervention is best evaluated when compared to a control group. We… Click to show full abstract

Clinical trials provide the foundational evidence that guide many patient-facing decisions however, the therapeutic effect and safety of an intervention is best evaluated when compared to a control group. We used ClinicalTrials.gov to describe the proportion of registered Phase III and IV cardiovascular clinical trials that contain a control group from 2009 through 2019. Of 1,677 registered Phase III and IV cardiovascular clinical trials, 81.2% contain a control group, and the annual prevalence remained unchanged between 2009 and 2019.

Keywords: cardiovascular clinical; control; clinicaltrials gov; prevalence; 2009 2019; clinical trials

Journal Title: American heart journal
Year Published: 2020

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