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Cicatricial ectropion and madarosis associated with panitumumab treatment of metastatic colorectal cancer

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Purpose To report a case of cicatricial ectropion and madarosis with the use of anti-epidermal growth factor receptor medication panitumumab. Observations An 82-year-old man with metastatic colorectal cancer presented with… Click to show full abstract

Purpose To report a case of cicatricial ectropion and madarosis with the use of anti-epidermal growth factor receptor medication panitumumab. Observations An 82-year-old man with metastatic colorectal cancer presented with cicatricial ectropion and madarosis after starting panitumumab, an anti-epidermal growth factor receptor medication used to treat metastatic colorectal cancer. His findings resolved several weeks after discontinuation of panitumumab and treatment with lubrication and antibiotic/steroid ointment. Conclusion This case demonstrates the importance to consider potential medication side effects when treating periocular conditions in patients taking anti-epidermal growth factor receptor (anti-EGFR) agents.

Keywords: cicatricial ectropion; ectropion madarosis; metastatic colorectal; colorectal cancer

Journal Title: American Journal of Ophthalmology Case Reports
Year Published: 2020

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