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expression of CCL3 (a Th1 chemoattractant) and higher expression of CCL2 (a Th2 chemoattractant) at 1 and 2 wpi. In vitro, cervical epithelial cells infected with Ct expressed IL-1b when… Click to show full abstract
expression of CCL3 (a Th1 chemoattractant) and higher expression of CCL2 (a Th2 chemoattractant) at 1 and 2 wpi. In vitro, cervical epithelial cells infected with Ct expressed IL-1b when treated with vehicle control. P4 further increased IL-1b expression during Ct infection, while LNG decreased IL-1b expression. CONCLUSIONS: LNG appears to blunt IL-1b production in response to Ct infection in vivo and in vitro. This may interfere with downstream chemokine production (e.g. IL-8, CCL3). This potential immunomodulatory effect could impact LNG users at higher risk for STIs.
Journal Title: American Journal of Obstetrics and Gynecology
Year Published: 2017
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