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OBJECTIVE: Aspirin prophylaxis is recommended for women at higher risk of preeclampsia; yet, there is no consensus about the optimal dose. Moreover, in North America, aspirin is routinely only available… Click to show full abstract
OBJECTIVE: Aspirin prophylaxis is recommended for women at higher risk of preeclampsia; yet, there is no consensus about the optimal dose. Moreover, in North America, aspirin is routinely only available in 81 mg and 325 mg tablets. While a recent metaanalysis suggested a dose-response effect, limitations therein included the inability to control for trial effects and maternal risk factors and a susceptibility to publication bias. Metaanalyses that use aggregate data pooled from different randomized controlled trials (RCTs) are also more likely to overestimate aspirin’s efficacy compared with those metaanalyses that use
Journal Title: American Journal of Obstetrics and Gynecology
Year Published: 2018
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