LAUSR

102 Fetal membrane exosome profiling in vitro reveals distinct pathways induced by infection and inflammation Luis A. Monsivais, Samantha Sheller-Miller, Rheanna Urrabaz-Garza, George Saade, Christopher L. Dixon, Ramkumar Menon The University of Texas Medical Branch, Galveston, TX, The University of Texs Medical Branch, Galveston, TX OBJECTIVE: Fetal inflammatory response to infectious and noninfectious challenges contribute to spontaneous preterm birth and pPROM. We have previously shown that fetal inflammatory signals can be propagated from fetal to maternal blood (biomarker) and tissues to initiate labor (function) via exosomes. Exosomes cargo reflects the functional state of their origin cell. In this study, differential expression of proteomic exosome cargo derived from human fetal membrane explants (FME) exposed to inflammatory and infectious stimuli was determined to understand the pathophysiologic state of fetal cell.