LAUSR

additional survivors compared to immediate administration at 22 weeks. Overall, delaying administration of antenatal steroids by three weeks led to higher QALYS when compared to immediate treatment. However, there would be 10 more neonates with respiratory distress syndromes, 20 more intraventricular hemorrhage, and 11 more children with neurodevelopmental delay. With sensitivity analysis, we found that as long as the probability of survival at 25 weeks gestation is less than 81%, then delaying administration by three weeks remains the optimal strategy. CONCLUSION: Our results support that the optimal time for administration of antenatal corticosteroids in women with PPROM at 22 weeks is three weeks after presentation at 25 weeks gestation to reduce mortality and minimize morbidity. These findings can be used to counsel women presenting in the periviable period.