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Preeclampsia increases the risk for longterm endocrine disease of the offspring: 792

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STUDY DESIGN: A population-based cohort analysis including deliveries between the years 1991 to 2014 in a tertiary referral hospital was conducted. Incidence of hospitalizations (up to age 18 years) due… Click to show full abstract

STUDY DESIGN: A population-based cohort analysis including deliveries between the years 1991 to 2014 in a tertiary referral hospital was conducted. Incidence of hospitalizations (up to age 18 years) due to various neurological conditions was compared between offspring of both groups. Kaplan-Meyer curve was used to assess cumulative hospitalization incidence. Cox proportional hazards model was used to control for baseline selected confounders. RESULTS: During the study period 206,731 deliveries met the inclusion criteria. Of those, 0.2% (n1⁄4343) were complicated by shoulder dystocia. In most of the investigated neurological conditions, including the risk for cerebral palsy, no significant differences were found between offspring of both groups (Table). Similarly, Kaplan-Meyer survival curve revealed comparable rates of cumulative neurological-related hospitalization in both groups (log rank p-value1⁄40.342; Figure). Using a Cox proportional hazards model to control for gestational age, shoulder dystocia did not appear to be independently associated with total neurological hospitalization (adjusted HR 1⁄4 0.73; 95% CI 0.36-1.47; p1⁄40.381).

Keywords: endocrine disease; longterm endocrine; preeclampsia increases; risk longterm; disease offspring; increases risk

Journal Title: American Journal of Obstetrics and Gynecology
Year Published: 2019

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