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872 Age-specific anti-mullerian hormone (AMH) and preeclampsia: a 15-year cohort study Hadi Erfani, Maryam Rahmati, Mohammad Ali Mansournia, Fereidoun Azizi, Seyed Ali Montazeri, Alireza A. Shamshirsaz, Fahimeh Ramezani Tehrani Baylor College of Medicine, Houston, TX, Research Institute for Endocrine Sciences – WHO Collaborating Center, Tehran, Tehran, Iran, Department of Epidemiology and Biostatistics, School of Public Health, Tehran, Tehran, Iran OBJECTIVE: To investigate if there is any association between ovarian reserve status and preeclampsia. STUDY DESIGN: This longitudinal study was conducted on participants of Tehran Lipid and Glucose Study, an ongoing population based cohort study with 15 years follow up. Ovarian reserve status was identified according to age specific AMH levels, calculated using the exponentialenormal 3-parameter model. Comparisons between those with and without preeclampsia were made using appropriate statistical methods. The association between age specific AMH and Preeclampsia was evaluated based on Buckley James regression method. RESULTS: 781 women, aged 20 -50 years, met eligibility criteria: 80 and 701 with and without confirmed preeclampsia, respectively. Prevalence of preeclampsia were 23 (11.1%), 12 (6.4 %), 26 (13.3%) and 19 (10%) in 1st, 2nd, 3rd and 4th quartiles of age specific AMH, respectively (P 1⁄4 0.16). The median and inter quartile range of serum AMH level was 1.05 (0.36 e 2.2) mg/L in women with a history of preeclampsia compared with 0.85 (0.28 e 2.1) mg/L in women with normotensive pregnancies. Based on Buckley James regression method, decrease in AMH levels, with increasing age and BMI, was not statistically different in PE compared with that for women with normotensive pregnancies. Logistic regression analysis, with having variables age-specific AMH quartile, smoking status, BMI and systolic blood pressure in the model, revealed no association between preeclampsia and age-specific AMH quartiles. Also ROC analysis on age-specific AMH showed no predictive performance for preeclampsia; area under curve (95% CI) was 0.54 (0.45 e 0.63) (P 1⁄4 0.40).