LAUSR

Supplem 921 A new pipeline for clinicopathological and molecular placental research Stephanie Barak, Julia J. O’Reilly, Homa K. Ahmadzia, Alexis C. Gimovsky, Charles J. Macri, Anna A. Penn The George Washington University School of Medicine and Health Sciences, Washington, DC, Children’s Research Institute, Children’s National Medical Center, Washington, DC, Children’s National Medical Center, Washington, DC OBJECTIVE: The placenta is at the core of many pregnancy pathologies, but we have limited knowledge about placental function because of two key research barriers: 1) until recently, there were no consensus guidelines for sample collection and pathologic diagnosis; and 2) limited tools are available to conduct molecular analysis of stored placental samples. We aimed to create a searchable and extensive population-based placental database of pathologic diagnoses and to validate molecular methods to allow for future gene expression studies on formalin fixed paraffin embedded (FFPE) placental blocks. STUDY DESIGN:We used a single university-based hospital’s collection of placental FFPE blocks and matched electronic medical records. Placentas from all deliveries, regardless of clinical indication, were assessed and stored from 2012-2017, providing an unbiased cohort of placental samples. We built an IRB-approved Research Electronic Data Capture (REDCap) database and included: maternal pre, peri and post-partum conditions, fetal outcome, macroscopic and microscopic placental findings. This database can be easily