LAUSR

espite a scanty evidence base, the concurrent use of two or more antipsychotic medications has become increasingly prevalent. The limited data on this practice provide no support for its effectiveness, except for the potential utility of adding a second antipsychotic agent to clozapine in patients with otherwise treatment-refractory schizophrenia. A number of adverse associations of antipsychotic combinations have been reported, including higher mortality, an increased risk of a range of side-effects, adverse drug interactions, decreased treatment adherence, and greater costs. We evaluate the appropriateness of the many rationales for antipsychotic combinations and outline recommendations for its place in antipsychotic therapy.